The soprano was born in Lodz and studied at the Frédéric Chopin Academy of Music in Warsaw with Jolanta Janucik and at the University of Arts in Graz with Joanna Borowska and Gottfried Hornik. She took master classes with Ryszard Karczykowski, Helena Lazarska and Teresa Zylis-Gara.

After first appearances in Warsaw, she made her international debut in 2007 as Adele in Die Fledermaus at the Palace Theater in Schönbrunn.

She participated in the Young Singers Project of the Salzburg Festival in 2009 and performed at its final concert at the Mozarteum. This was followed by engagements at leading international houses and festivals: she was, among others. Woglinde (Götterdämmerung) in Aix-en-Provence and at the Salzburg Festival, Adele (Die Fledermaus) at the Vienna State Opera, Clorinda (La Cenerentola) at the Glyndebourne Festival, Taumännchen (Hänsel und Gretel) at the Royal Opera House Covent Garden, Flaminia (Il mondo della luna) at the Bruckner Festival in Linz, Amina (La sonnambula) and Giulietta (I Capuleti e i Montecchi) in Graz, Ilia (Idomeneo) at the Komische Oper in Berlin, Gilda (Rigoletto) in Limoges, Kazan and Vilnius, the title role in Stravinsky’s Nightingale in Warsaw. She performed Sandrina (La finta giardiniera) at the State Opera in Berlin and in Bonn, Zerbinetta (Ariadne auf Naxos) with the Warsaw Philharmonic Orchestra and a Flower Girl (Parsifal) at the Bayreuth Festival. She has sung Queen of the Night around the world, for companies including Vienna State Opera, Volksoper Vinna, Komische Oper Berlin, Washington National Opera, Berlin State Opera, Dresden Semperoper ,Oper Frankfurt, Opéra Bastille in Paris and at the Royal Opera House Covent Garden.

Anna Siminska is also a frequent guest on international concert stages (Musikverein Vienna, Festpielhaus Baden-Baden, KKL Lucerne, etc.) and has also appeared in the BBC documentary Pappano’ s Classical Voices alongside Joyce DiDonato, Diana Damrau, Anna Netrebko and Jonas Kaufmann.